Description
An ACE inhibitor (IC50 = 23 nM for the rabbit lung enzyme); inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively); angiotensin I-induced pressor responses in conscious normotensive rats; reduces mean blood pressure in 2K-1C rats and SHRs; reduces HSV-1-induced cytopathogenicity in SH-SY5Y human neuroblastoma cells